5/15/2023 0 Comments Amadine thierry durand![]() ![]() The prognosis for this disease is poor and typical treatments are of limited efficacy. ![]() Together, Owkin, CLB, and Institut Curie decided to investigate breast cancer because of its incidence, specifically triple-negative breast cancer. (A federation of French medical centers that are pioneering cancer research and improving patient care). Thus, Owkin turned to its internationally-renowned partners CLB and Institut Curie, both part of UNICANCER. To implement federated learning, we needed to identify two or more medical centers with curated datasets of similar data types. In this article, we outline a roadmap for how we got here and what we learned along the way. It is also an example of outstanding collaboration and an empowering conclusion to our journey. This proof-of-concept for federated learning via Owkin Connect is a remarkable technical triumph. The path to this incredible achievement was not straightforward however, it was full of many discoveries and valuable lessons. Additionally, two datasets and more than 40 talented and dedicated people from Owkin, Centre Léon Bérard (‘CLB’), and Institut Curie) contributed to this success. This model was a proof-of-concept for “Connect”. In January 2020, Connect enabled the first-ever federated deep learning model (‘Model’) trained on distributed histology images stored behind hospital firewalls. It enables distributed machine learning training without aggregating or collecting private data. This innovative software is our proprietary federated learning framework that ‘connects’ multiple data sources. In doing this, we connect medical researchers, biopharma companies, and data scientists in a collaborative, privacy-preserving Data Platform.Īccess to large-scale, meaningful medical data is a significant challenge in healthcare. As a result, Owkin has dedicated three years of R&D to develop Owkin Connect (‘Connect’). doi: 10.1016/j.plipres.2016.01.001.At Owkin, our mission is to fuse AI and clinical research to unlock medical discoveries. Long-chain polyunsaturated fatty acid biosynthesis in chordates: Insights into the evolution of Fads and Elovl gene repertoire. ![]() Algal biorefinery models with self-sustainable closed loop approach: Trends and prospective for blue-bioeconomy. Venkata M.S., Hemalatha M., Chakraborty D., Chatterjee S., Ranadheer P., Kona R. doi: 10.1007/s1012-y.īrodie J., Chan C.X., de Clerck O., Cock J.M., Coelho S.M., Gachon C., Grossman A.R., Mock T., Raven J.A., Smith A.G., et al. Molecular detection, quantification, and diversity evaluation of microalgae. Rethinking the marine carbon cycle: Factoring in the multifarious lifestyles of microbes. Worden A.Z., Follows M.J., Giovannoni S.J., Wilken S., Zimmerman A.E., Keeling P.J. PUFAs isoprostanoids micro-LC-MS/MS microalgae oxidative stress. This study paves the way to further studying the physiological roles of isoprostanoids in marine microalgae and exploring these organisms as bioresources for isoprostanoid production. lutea, while variations were monitored for the other two algae. In the presence of hydrogen peroxide, no significant changes were observed for C. No significant variations in the content of oxidized derivatives were observed for Rhodomonas salina and Chaetoceros gracilis under copper stress, whereas increases in the production of C18-, C20- and C22-derived isoprostanoids were monitored in Tisochrysis lutea and Phaeodactylum tricornutum. A good correlation was observed between the most abundant polyunsaturated fatty acids (PUFAs) produced by the investigated microalgal species and their isoprostanoid profiles. To fill this gap, the current investigation aimed at profiling isoprostanoids by liquid chromatography -mass spectrometry/mass spectrometry (LC-MS/MS) in four marine microalgae. So far, there have been only a few studies reporting isoprostanoid productions in algae. Due to the presence of numerous double-bonds, such molecules can be oxidized nonenzymatically, and this results in the biosynthesis of high-value bioactive metabolites named isoprostanoids. For example, these organisms can synthesize different polyunsaturated fatty acids, such as those found in land plants and oily fish. Algae result from a complex evolutionary history that shapes their metabolic network. ![]()
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